Premium
Coupling of rat somatostatin receptor subtypes to a G‐protein gated inwardly rectifying potassium channel (GIRK1)
Author(s) -
Kreienkamp Hans-Jürgen,
Hönck Hans-Hinrich,
Richter Dietmar
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)01437-3
Subject(s) - g protein coupled inwardly rectifying potassium channel , somatostatin receptor 2 , somatostatin receptor , somatostatin , potassium channel , somatostatin receptor 1 , endocrinology , medicine , inward rectifier potassium ion channel , xenopus , chemistry , biophysics , coupling (piping) , receptor , microbiology and biotechnology , biology , g protein , ion channel , biochemistry , materials science , gene , metallurgy
The five different rat somatostatin receptor subtypes (SSTR1–SSTR5) were coexpressed with a subunit of G‐protein gated inwardly rectifying potassium channel (GIRK1) in Xenopus oocytes. SSTR2–SSTR5, but not SSTR1 coupled efficiently to the activation of GIRK currents when stimulated by SST14 or SST28. A comparison of the dose‐response curves and of the maximum currents obtained indicates that SSTR2 couples most efficiently to this effector, supporting the notion that SSTR2 is involved in activation of potassium conductances by SST in vivo.