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Human monocyte‐derived and CD34 + cell‐derived dendritic cells express functional receptors for platelet activating factor
Author(s) -
Sozzani Silvano,
Longoni Daniela,
Bonecchi Raffaella,
Luini Walter,
Bersani Laura,
D'Amico Giovanna,
Borsatti Alessandro,
Bussolino Federico,
Allavena Paola,
Mantovani Alberto
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)01358-6
Subject(s) - microbiology and biotechnology , receptor , platelet activating factor receptor , dendritic cell , cytokine , platelet activating factor , biology , monocyte , population , chemistry , antigen , immunology , biochemistry , medicine , environmental health , antagonist
Dendritic cells (DC) are a heterogeneous population of specialized antigen presenting cells that exhibit complex trafficking properties. DC differentiated in vitro from both peripheral monocytes and CD34 + cells expressed mRNA for platelet activating factor (PAF) receptor. Expression of PAF receptor was increased by TNFα, a prototypic inflammatory cytokine that induces differentiation and in vivo mobilization of DC. PAF induced in vitro directional migration of DC obtained from both precursor cells through its specific receptor. Since DC are highly motile cells, protein chemoattractants as well as bioactive phospholipids are likely to contribute to tissue localization of DC, in vivo.