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Promoters of epithelialization induce expression of vascular endothelial growth factor in human gastric epithelial cells in primary culture
Author(s) -
Takahashi Morio,
Ogura Keiji,
Maeda Shin,
Mori Kiyoshi,
Mafune Ken-ichi,
Mikami Yasuyo,
Terano Akira,
Omata Masao
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)01354-9
Subject(s) - hepatocyte growth factor , epidermal growth factor , angiogenesis , vascular endothelial growth factor , growth factor receptor inhibitor , microbiology and biotechnology , cancer research , growth factor , vascular endothelial growth factor c , vascular endothelial growth factor b , receptor , biology , vascular endothelial growth factor a , chemistry , endocrinology , medicine , vegf receptors
Both epithelialization and angiogenesis are indispensable processes in gastric ulcer healing. Coordination between these processes has not been well studied. In the present study, we have established a new primary culture system of human gastric epithelial cells and investigated the effect of epithelialization stimulants on a specific angiogenic factor, vascular endothelial growth characterized as epithelial cells. Both epithelialization stimulants, hepatocyte growth factor (HGF) and epidermal growth factor (EGF), significantly stimulated vascular EGF expression in gastric epithelial cells. HGF and EGF receptors were expressed by the cells, suggesting that regulation may be mediated through specific receptors.