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Protective effects of the lipophilic redox conjugate tocopheryl succinyl‐ethyl ferulate on HIV replication
Author(s) -
Edeas Marvin A,
Claise Catherine,
Vergnes Laurent,
Barthelemy Sophie,
Labidalle Serge,
Lindenbaum Albert
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)01335-5
Subject(s) - lipophilicity , chemistry , tocopherol , conjugate , tocopheryl acetate , biochemistry , antioxidant , vitamin e , mathematical analysis , mathematics
Previously, we demonstrated that ferulate ethyl and tocopherol reduced HIV replication. In this study, we investigate whether the conjugation of both compounds ( O ‐tocopheryl succinyl O ‐ethyl ferulate) can increase HIV inhibition. We show here for the first time that O ‐tocopheryl succinyl O ‐ethyl ferulate inhibits 80% of HIV replication (HIV‐1 acute infection and HIV transmission), inhibits cell lipoperoxidation and prevents cellular glutathione consumption. Compared to ferulate ethyl and tocopheryl succinyl, O ‐tocopheryl succinyl O ‐ethyl ferulate inhibits more HIV replication. This may be due in part to the great increase in the lipophilicity of this compound.