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Expression of B‐type endothelin receptor gene during neural development
Author(s) -
Tsaur Meei-Ling,
Wan Yi-Chiou,
Lai Fang-Pin,
Cheng Hwei-Fang
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)01295-7
Subject(s) - biology , choroid plexus , in situ hybridization , subependymal zone , ependymal cell , subventricular zone , neural development , microbiology and biotechnology , paracrine signalling , endothelin 3 , endothelin receptor , gene expression , receptor , endocrinology , gene , anatomy , central nervous system , endothelins , neural stem cell , genetics , stem cell
Mutations of the B‐type endothelin receptor (ETRB) gene have been found to cause defects in the development of enteric neurons, which resulted in aganglionic megacolon in rodents and humans. To determine the distribution of ETRB mRNA during neural development, mainly in the CNS, in situ hybridization was applied at various developmental stages of rat. ETRB gene was abundantly expressed prenatally in the ventricular and subventricular zones, as well as postnatally in the ependymal and subependymal cells. ETRB mRNA was also strongly detected prenatally in the dorsal root ganglia, as well as postnatally in the cerebellar Bergmann glial cells and epithelial cells of choroid plexus. Our data suggest that ETRB acts as a regulator in the differentiation, proliferation, or migration of neural cells during development.