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Alu sequences
Author(s) -
Mighell A.J.,
Markham A.F.,
Robinson P.A.
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)01259-3
Subject(s) - alu element , biology , rna polymerase iii , nucleic acid , genetics , gene , dna sequencing , dna , rna , computational biology , human genome , genome , rna polymerase
Alu sequences are frequently encountered during study of human genomic nucleic acid and form a major component of repetitive DNA. This review describes the origin of Alu sequences and their subsequent amplification and evolution into distinct subfamilies. In recent years a number of different functional roles for Alu sequences have been described. The multiple influences of Alu sequences on RNA polymerase II‐mediated gene expression and the presence of Alu sequences in RNA polymerase III‐generated transcripts are discussed.