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NGF exhibits a pro‐apoptotic activity for human vascular smooth muscle cells that is inhibited by TGFβ1
Author(s) -
Bono Françoise,
Lamarche Isabelle,
Herbert Jean-Marc
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)01215-5
Subject(s) - apoptosis , vascular smooth muscle , transforming growth factor , in vitro , microbiology and biotechnology , medicine , chemistry , smooth muscle , endocrinology , cancer research , pharmacology , biology , biochemistry
These results indicate that, at least in vitro, TGFβ1 can inhibit the pro‐apoptotic activity of NGF for SMCs therefore suggesting that TGFβ1 has the capacity to diminish the deleterious consequences of an excitotoxic or ischemic injury that might occur during atherogenesis or following angioplasty.