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TNF‐α induces apoptosis in rat fetal brown adipocytes in primary culture
Author(s) -
Porras Almudena,
Álvarez Alberto M,
Valladares Amparo,
Benito Manuel
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)01204-0
Subject(s) - apoptosis , tumor necrosis factor alpha , primary culture , microbiology and biotechnology , cell culture , fetus , programmed cell death , chemistry , biology , endocrinology , pregnancy , biochemistry , genetics
The effect of TNF‐α on cell death in rat fetal brown adipocytes maintained in primary culture was determined. TNF‐α inhibited proliferation and induced apoptosis in these cells. Most of the cells undergoing apoptosis after TNF‐α treatment did not express PCNA, suggesting an induction of apoptosis by TNF‐α in non‐proliferative cells. IGF‐I but not EGF prevented TNF‐α‐induced apoptosis.