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The Su(Ste) repeat in the Y chromosome and βCK2tes gene encode predicted isoforms of regulatory β‐subunit of protein kinase CK2 in Drosophila melanogaster
Author(s) -
Kalmykova A.I.,
Dobritsa A.A.,
Gvozdev V.A.
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)01195-2
Subject(s) - gene , genetics , exon , biology , autophosphorylation , gene isoform , scn3a , protein subunit , zinc finger , rna splicing , intron , alternative splicing , drosophila melanogaster , microbiology and biotechnology , protein kinase a , kinase , g alpha subunit , rna , transcription factor
We report an exon‐intron structure of the Su(Ste) repeat capable of encoding an isoform of the β‐subunit of protein kinase CK2. The predicted Su(Ste) gene product contains a drastically changed amino acid sequence of the N‐terminal fragment as compared to the earlier described bCK2tes gene considered to be an ancestor of the Su(Ste) repeats. The following peculiarities of molecular divergence of the Su(Ste) and βCK2tes genes are revealed: damages of the autophosphorylation site; usage of an alternative splicing site instead of a damaged one; conservation of the zinc finger domain in spite of local ORF alterations.