Premium
Mechanisms of cycloheximide‐induced apoptosis in liver cells
Author(s) -
Alessenko Alice V,
Boikov Peter Ya,
Filippova Gali,
Khrenov Alexey V,
Loginov Anatoliy S,
Makarieva Elena D
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)01161-7
Subject(s) - cycloheximide , apoptosis , microbiology and biotechnology , chemistry , biochemistry , protein biosynthesis , biology
Cycloheximide in sublethal doses caused apoptosis in liver cells in vivo, inducing c‐ myc , c‐ fos , c‐ jun and p53 genes and accumulation of sphingosine, a toxic product of the sphingomyelin cycle. These data support the hypothesis that continuous synthesis of labile protective proteins is required to restrain apoptosis in liver; sphingosine might be important in mediating cycloheximide‐induced apoptosis as an endogenous modulator of protein kinase C activity.