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Concomitant and hormonally regulated expression of trp genes in bovine aortic endothelial cells
Author(s) -
Chang Albert S.,
Chang Sharon M.,
Garcia Reynaldo L.,
Schilling William P.
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)01155-1
Subject(s) - retinoic acid , gene , transient receptor potential channel , endocrinology , medicine , biology , hormone , microbiology and biotechnology , chemistry , receptor , biochemistry
Recent findings have suggested that the vertebrate trp family of channel proteins is the structural basis for Ca 2+ influx through the capacitative calcium entry (CCE) pathway. We have discerned, in bovine aortic endothelial cells, the concomitant expression of four such vertebrate genes: trp‐1 (two splice variants), trp‐3 , trp‐4 and trp‐5 . Exogenous hormones rendered dynamic effects on the transcript levels of these genes. Most notably, β‐estradiol significantly down‐regulated trp‐4 while trans ‐retinoic acid dramatically up‐regulated trp‐5 ; yet these hormones rendered little change in CCE. These findings suggest that the extent of a given trp channel's participation in CCE is not reflected in alterations of its transcript level.