Premium
Matrilin‐3 from chicken cartilage
Author(s) -
Belluoccio Daniele,
Trueb Beat
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)01126-5
Subject(s) - cartilage , chemistry , microbiology and biotechnology , computational biology , biophysics , anatomy , biology
By subtractive cDNA cloning we have identified a novel constituent of chicken cartilage termed matrilin‐3. This constituent is encoded by a mRNA of 2.2 kbp whose expression is restricted to cartilaginous tissues. The predicted protein is composed of 452 amino acids with a molecular mass of 49 kDa. It contains a single von Willebrand factor A‐like domain, four epidermal growth factor‐like repeats and an α‐helical region which may induce the formation of oligomers via a coiled‐coil. The primary structure is similar to that of matrilin‐1 which is also expressed in a cartilage‐specific manner. This similarity suggests that the genes for the two proteins may have evolved from a common ancestor by gene duplication.