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Neokyotorphin and neokyotorphin (1–4): secretion by erythrocytes and regulation of tumor cell growth
Author(s) -
Blishchenko Elena Yu,
Mernenko Olga A,
Yatskin Oleg N,
Ziganshin Rustam H,
Philippova Marina M,
Karelin Andrei A,
Ivanov Vadim T
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)00991-5
Subject(s) - tumor cells , secretion , fragment (logic) , hemoglobin , chemistry , red blood cell , microbiology and biotechnology , cell growth , biochemistry , biology , cancer research , computer science , programming language
Human erythrocytes release neokyotorphin, the 137–141 fragment of hemoglobin α‐chain into the supernatant of red blood cells primary culture. However, the neokyotorphin fragment 1–4 that is formed together with neokyotorphin inside the red blood cells and in various tissues is not found in the supernatant. Both neokyotorphin and its 1–4 fragment were shown to stimulate proliferation of L929 tumor cells.