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A cisternal maturation mechanism can explain the asymmetry of the Golgi stack
Author(s) -
Benjamin S. Glick,
Timothy C. Elston,
George Oster
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)00984-8
Subject(s) - copi , golgi apparatus , vesicle , microbiology and biotechnology , stack (abstract data type) , copii , biophysics , cisterna , biology , axoplasmic transport , secretory pathway , chemistry , endoplasmic reticulum , biochemistry , membrane , computer science , programming language
Morphological data suggest that Golgi cisternae form at the cis ‐face of the stack and then progressively mature into trans ‐cisternae. However, other studies indicate that COPI vesicles transport material between Golgi cisternae. These two observations can be reconciled by assuming that cisternae carry secretory cargo through the stack in the anterograde direction, while COPI vesicles transport Golgi enzymes in the retrograde direction. This model provides a mechanism for cisternal maturation. If Golgi enzymes compete with one another for packaging into COPI vesicles, we can account for the asymmetric distribution of enzymes across the stack.