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A single nucleotide is a sufficient 5′ untranslated region for translation in an eukaryotic in vitro system
Author(s) -
Hughes Martin J.G,
Andrews David W
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)00965-4
Subject(s) - translation (biology) , five prime untranslated region , untranslated region , biology , eukaryotic translation , genetics , translational regulation , rna , computational biology , microbiology and biotechnology , nucleotide , protein biosynthesis , in vitro , three prime untranslated region , messenger rna , gene
The 5′ untranslated region of an RNA molecule is thought to play an important role in the regulation of translation. Following a recent report that a single nucleotide is sufficient to act in this role in the unicellular organism Giardia , we show that this is also the case for a mammalian in vitro system. These results also demonstrate that an RNA can initiate translation from a start codon where an ideal translational consensus sequence is impossible.