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Early tumor effect on splenic Th lymphocytes in mice
Author(s) -
Segura Juan A,
Barbero Laura G,
Márquez Javier
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)00943-5
Subject(s) - immune system , ascites , spleen , ascitic fluid , biology , cell , inoculation , immunology , tumor cells , cancer research , pathology , medicine , genetics
Tumors are characterized by their ability to avoid the host immune system. Ehrlich ascites tumor cells were used to investigate the early alterations of the host immune system after tumor inoculation. The results show that frequencies of splenic Th lymphocytes were drastically reduced during tumor growth, reaching a minimum only two days after tumor inoculation. The frequency of splenic CD4 + lymphocytes expressing IFN‐γ was significantly increased, although the total number was unchanged, suggesting that there was no net induction of Th1‐type response. Splenic macrophages were increased, in both frequency and cell number, after four days of tumor growth. The same pattern was observed when mice were inoculated with cell free ascitic fluid. TGF‐β precursors were detected in tumor cells as well as in ascitic fluid. The data suggest that tumor actively interacts with host immune system by means of tumor cell secreted factors.