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Alternatively spliced forms of the cGMP‐gated channel in human keratinocytes
Author(s) -
Oda Yuko,
Timpe Leslie C,
McKenzie Roderick C,
Sauder Daniel N,
Largman Corey,
Mauro Theodora
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)00927-7
Subject(s) - keratinocyte , extracellular , microbiology and biotechnology , protein subunit , intracellular , transmembrane domain , alternative splicing , calcium channel , epidermis (zoology) , ion channel , transmembrane protein , biology , chemistry , calcium , biochemistry , gene , genetics , messenger rna , anatomy , cell culture , receptor , organic chemistry
Alternatively spliced forms of the α subunit of the cGMP‐gated channel have been cloned from human keratinocytes. One form encodes a complete channel which is almost identical to the rod photoreceptor. A second spliced variant would encode a protein missing a portion of the intracellular hydrophilic domain and the putative first transmembrane domain. Both complete and spliced variants of the channel also were found in epidermis. The expression of the complete form of the channel was induced by levels of extracellular calcium which promote keratinocyte differentiation. The cGMP‐gated channel may play an important role in calcium induced keratinocyte differentiation by mediating Ca 2+ entry.