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Glycoprotein VI is the collagen receptor in platelets which underlies tyrosine phosphorylation of the Fc receptor γ‐chain
Author(s) -
Gibbins Jonathan M,
Okuma Minoru,
Farndale Richard,
Barnes Michael,
Watson Stephen P
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)00926-5
Subject(s) - gpvi , syk , tyrosine phosphorylation , phosphorylation , chemistry , collagen receptor , receptor tyrosine kinase , platelet membrane glycoprotein , receptor , tyrosine kinase , microbiology and biotechnology , biochemistry , biology , integrin
We have recently shown that collagen activates platelets through a pathway dependent on the Fc receptor γ‐chain and the tyrosine kinase Syk. We report here that the Fc receptor γ‐chain and the candidate collagen receptor glycoprotein VI (GPVI) co‐associate. Furthermore, cross‐linking GPVI stimulates a similar pattern of tyrosine phosphorylation to that stimulated by collagen, including tyrosine phosphorylation of Fc receptor γ‐chain. These results support a model where GPVI couples collagen‐stimulation of platelets to phosphorylation of the Fc receptor γ‐chain leading to activation of Syk and phospholipase Cγ2.