Premium
Antioxidant role of melatonin in lipid peroxidation of human LDL
Author(s) -
Abuja Peter M.,
Liebmann Peter,
Hayn Marianne,
Schauenstein Konrad,
Esterbauer Hermann
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)00918-6
Subject(s) - melatonin , lipid peroxidation , antioxidant , chemistry , lipid oxidation , biochemistry , incubation , medicine , endocrinology , biology
It is concluded that melatonin is not incorporated into LDL in sufficient concentrations to prevent lipid peroxidation effectively. When melatonin is present in the incubation medium during oxidation, a partitioning equilibrium between aqueous and lipid phase is established. Only under these conditions can melatonin act as a chain breaking antioxidant. The concentrations required, however, are far beyond those found in human plasma. Therefore, the data in this study do not support a direct physiological relevance of melatonin as an antioxidant in lipid peroxidation processes.