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pmg ‐1, a novel gene specifically expressed during the invasive growth phase of the mammary gland at puberty
Author(s) -
Kuhn Franziska,
Andres Anne-Catherine
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)00836-3
Subject(s) - mammary gland , biology , epithelium , stroma , gene , carcinogenesis , gene expression , in situ hybridization , endocrinology , medicine , cancer research , genetics , immunology , immunohistochemistry , cancer , breast cancer
The acquisition of invasive properties is a crucial event during carcinogenesis, determining the clinical outcome. The mammary gland at puberty provides an ideal model for investigating the induction and control of invasive growth. During this growth phase, the mammary epithelium participates in a normal, hormonally controlled invasive penetration into the stroma. We have applied the differential display method to search for genes specifically activated during this developmental stage. We have identified and molecularly characterized a novel p ubertal m ammary g land specific gene, pmg ‐1. This gene is conserved in mammals and encodes a protein of 19.9 kDa. Northern blotting and in situ hybridization revealed that pmg ‐1 expression was exquisitely restricted to the epithelium at early puberty. To our knowledge this represents the first isolation of a gene specifically associated with the induction of mammary epithelial invasiveness at puberty.