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Sterol 22‐desaturase, cytochrome P45061, possesses activity in xenobiotic metabolism
Author(s) -
Kelly Steven L.,
Lamb David C.,
Kelly Diane E.
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)00785-0
Subject(s) - xenobiotic , yeast , biochemistry , enzyme , ergosterol , biology , drug metabolism , cytochrome p450 , chemistry , genetics
CYP61 was revealed in the sequencing of the yeast genome on chromosome XIII and was the last member of the CYP superfamily in yeast to be discovered. We show here that besides the housekeeping role in 22‐desaturation during ergosterol biosynthesis the enzyme is also that responsible for benzo(a)pyrene metabolism/promutagen activation by yeast in genotoxicity assays. This enzyme may represent an ancestral activity for the superfamily which allowed xenobiotic metabolism for the first time.