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vesl , a gene encoding VASP/Ena family related protein, is upregulated during seizure, long‐term potentiation and synaptogenesis 1
Author(s) -
Kato Akihiko,
Ozawa Fumiko,
Saitoh Yoshito,
Hirai Keiko,
Inokuchi Kaoru
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)00775-8
Subject(s) - synaptogenesis , long term potentiation , dentate gyrus , hippocampal formation , synaptic plasticity , kainic acid , microbiology and biotechnology , biology , neurotransmitter receptor , postsynaptic density , nmda receptor , neuroscience , chemistry , receptor , glutamate receptor , biochemistry
We have isolated a novel cDNA, vesl , that was induced during convulsive seizure in the rat hippocampus. The vesl gene encodes a protein of 186 amino acids that has significant homology to the EVH1 domain of the VASP/Ena family of proteins implicated in the control of microfilament dynamics. The expression of vesl mRNA was induced in the granule cell layer during persistent long‐term potentiation (LTP) of the dentate gyrus in an NMDA receptor‐dependent manner. Furthermore, vesl mRNA was expressed at a high level during hippocampal synaptogenesis. We suggest that the Vesl protein may be involved in the structural changes that occur at synapses during long‐lasting neuronal plasticity and development.