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Effects of melatonin in isolated rat papillary muscle
Author(s) -
Abete Pasquale,
Bianco Sabatino,
Calabrese Claudio,
Napoli Claudio,
Cacciatore Francesco,
Ferrara Nicola,
Rengo Franco
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)00749-7
Subject(s) - melatonin , medicine , endocrinology , melatonin receptor , forskolin , papillary muscle , contractility , receptor , chemistry , adenylate kinase , antagonist , biology
In conclusion, we found that melatonin possess anti‐adrenergic effect in isolated rat papillary muscle. This phenomenon was abolished in the presence of its receptor antagonist N ‐acetyltryptamine demonstrating that melatonin operates through a specific cardiac receptor. The reduction of contractility increase, induced by forskolin‐stimulated adenylate cyclase, shows that melatonin may act through a reduction of cyclic AMP accumulation.