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Further studies on the recoupling effect of 6‐ketocholestanol upon oxidative phosphorylation in uncoupled liver mitochondria
Author(s) -
Cuéllar Adela,
Ramı́rez Jorge,
Infante Victor M.,
Chávez Edmundo
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)00741-2
Subject(s) - oxidative phosphorylation , mitochondrion , chemistry , phosphorylation , microbiology and biotechnology , biochemistry , biophysics , biology
The effect of 6‐ketocholestanol was studied on CCCP‐induced uncoupling in liver mitochondria, submitochondrial particles and cytochrome oxidase proteoliposomes. It was found that 6‐ketocholestanol prevents and reverses uncoupling induced by nM concentrations of CCCP on the three systems assayed. As it was reported on kidney mitochondrial membranes [Chávez et al. (1996) FEBS Lett. 379, 305–308], the recoupling effect caused by 6‐ketocholestanol on submitochondrial particles and proteoliposomes could be due to a diminution of membrane fluidity.