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Structures of the O‐antigens of Proteus bacilli belonging to OX group (serogroups O1–O3) used in Weil‐Felix test
Author(s) -
Ziolkowski Andrzej,
Shashkov Alexander S.,
Swierzko Anna St.,
Senchenkova Sof'ya N.,
Toukach Filip V.,
Cedzynski Maciej,
Amano Ken-Ichi,
Kaca Wieslaw,
Knirel Yuriy A.
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)00694-7
Subject(s) - proteus , proteus vulgaris , antigen , rickettsiosis , microbiology and biotechnology , bacilli , polysaccharide , biology , serotype , group (periodic table) , chemistry , antibody , bacteria , serology , biochemistry , escherichia coli , antibacterial activity , gene , genetics , organic chemistry
Structures of the O‐specific polysaccharide chains of lipopolysaccharides from Proteus group OX strains (serogroups O1–O3) used as antigens in Weil‐Felix test for diagnosis of rickettsiosis, were established. From them, the acid‐labile polysaccharide of Proteus vulgaris OX19 (O1) is built up of the following branched pentasaccharide repeating units connected via a phosphate group: where QuiNAc stands for 2‐acetamido‐2,6‐dideoxyglucose ( N ‐acetylquinovosamine). The basis of serospecificity of the Proteus group OX antigens and their cross‐reactivity with human anti‐rickettsial antibodies is discussed.