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Alternative activation of transcriptional initiators in Drosophila melanogaster LINE promoters
Author(s) -
Minchiotti Gabriella,
Di Nocera Pier Paolo
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)00689-3
Subject(s) - promoter , enhancer , drosophila melanogaster , transcription (linguistics) , biology , genetics , transcription factor ii d , transcription factor , microbiology and biotechnology , gene , gene expression , linguistics , philosophy
In the Drosophila I, F and Doc LINEs, basal transcription is ensured by the functional interaction of initiator sequences with intragenic regulatory segments (B regions) which comprise distinct functional modules. Removing the B regions, as changing their composition or location, allowed different activators to stimulate transcription from novel initiators both in Doc and F promoters. The use of distinct initiators plausibly reflects the assembly of transcriptional complexes in which TFIID assumes alternative spatial conformations. The response of I, F and Doc promoters to the same enhancer is significantly influenced by the number, position and type of core elements present.