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The uptake of cholesterol at the small‐intestinal brush border membrane is inhibited by apolipoproteins
Author(s) -
Boffelli Dario,
Compassi Sabina,
Werder Moritz,
Weber Franz E,
Phillips Michael C,
Schulthess Georg,
Hauser Helmut
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)00658-3
Subject(s) - brush border , cholesterol , apolipoprotein b , chemistry , sterol , membrane , biochemistry , cholesterol 7 alpha hydroxylase , brush , biophysics , biology , vesicle , electrical engineering , engineering
The uptake of free and esterified cholesterol at the brush border membrane is protein‐mediated. Here we show that this sterol uptake is effectively inhibited by exchangeable serum apolipoproteins. Binding of the apolipoprotein to the brush border membrane mediates the inhibitory effect. Evidence is presented to show that the structural motif responsible for the inhibition is the amphipathic α‐helix.