Premium
The stimulatory effect of negative air ions and hydrogen peroxide on the activity of superoxide dismutase
Author(s) -
Kosenko E.A,
Kaminsky Yu.G,
Stavrovskaya I.G,
Sirota T.V,
Kondrashova M.N
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)00651-0
Subject(s) - superoxide dismutase , superoxide , hydrogen peroxide , chemistry , incubation , dismutase , ion , cytosol , biochemistry , reactive oxygen species , oxygen , enzyme , organic chemistry
The activity of erythrocyte cytosolic superoxide dismutase from rat, bovine, man and duck was considerably increased when measured after preparation or incubation in media pretreated with negative air ions (mostly superoxide) from electroeffluvial ion generator. 0.5–1.0 μM H 2 O 2 was found in incubation medium after treatment with air ions. The stimulatory effect of air ions on superoxide dismutase activity was mimicked by addition of 0.5–6 μM H 2 O 2 . The primary physicochemical mechanism of beneficial biological action of negative air ions is suggested to be related to the stimulation of superoxide dismutase activity by micromolar concentrations of H 2 O 2 .