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Hedgehog and patched gene expression in adult ocular tissues
Author(s) -
Takabatake Takashi,
Ogawa Masanori,
Takahashi Tadashi C,
Mizuno Makoto,
Okamoto Mitsumasa,
Takeshima Kazuhito
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)00645-5
Subject(s) - hedgehog , patched , retina , biology , cornea , retinal pigment epithelium , gene , retinal , hedgehog signaling pathway , gene expression , microbiology and biotechnology , genetics , neuroscience , biochemistry
We analysed the expression of members of the hh gene family in adult ocular tissues of newt, frog and mouse by RT‐PCR method. Shh displayed restricted expression in the neural retina that was conserved in each species analyzed. X‐bhh , X‐chh and mouse Ihh were detected in the iris and in the retinal pigment epithelium, while mouse Dhh was detected additionally in the neural retina and faintly in the cornea. We also found that two types of ptc genes, potential hh targets and receptors, were expressed in these tissues, suggesting the presence of active hh signalling there.