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A transcriptional modification motif encoded by homeobox and fork head genes
Author(s) -
Shimeld Sebastian M
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)00632-7
Subject(s) - homeobox , emx2 , transcription factor , transcription (linguistics) , genetics , motif (music) , gene , e box , biology , homeobox a1 , dna binding protein , microbiology and biotechnology , enhancer , linguistics , philosophy , physics , acoustics
Homeodomain and fork head domain proteins are thought to act as transcription factors by binding to specific DNA target sequences and interacting with other proteins. Here I describe a motif which is present in members of both groups of transcription factor and which has been shown to modulate their ability to activate transcription. The presence of this motif in both homeodomain and fork head proteins indicates they may control transcription by a similar molecular mechanism, perhaps by interacting with the same cofactors.