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The effect of some peptides from the hibernating brain on Ca 2+ current in cardiac cells and on the activity of septal neurons
Author(s) -
Kokoz Yu.M.,
Zenchenko K.I.,
Alekseev A.E.,
Korystova A.F.,
Lankina D.A.,
Ziganshin R.H.,
Mikhaleva I.I.,
Ivanov V.T.
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)00607-8
Subject(s) - ventricle , hibernation (computing) , chemistry , ground squirrel , biophysics , medicine , current (fluid) , biology , endocrinology , anatomy , physics , squirrel monkey , state (computer science) , algorithm , computer science , thermodynamics
The effects of the peptides TSKYR and DY isolated from the brain of hibernating ground squirrels on Ca 2+ current were studied. TSKYR activated Ca 2+ current in frog auricle fibers and in single cells from frog ventricle whereas DY blocked Ca 2+ current in both preparations. In isolated rat and ground squirrel cardiocytes, TSKYR had no effect on Ca 2+ current, and DY increased it. In brain slices of rat, DY blocked the activity of medial septal neurons. TSKYR increased activity of septal neurons at the initial phase, which was followed by decrease of neuronal activity.