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Expression of trypsin in vascular endothelial cells
Author(s) -
Koshikawa Naohiko,
Nagashima Yoji,
Miyagi Yohei,
Mizushima Hiroto,
Yanoma Shunsuke,
Yasumitsu Hidetaro,
Miyazaki Kaoru
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)00565-6
Subject(s) - trypsinogen , angiogenesis , endothelial stem cell , biology , in situ hybridization , trypsin , coagulation , microbiology and biotechnology , cancer research , messenger rna , gene , biochemistry , medicine , enzyme , in vitro
Proteinases produced by vascular endothelial cells are expected to play important roles in many biological processes. Here we report that human vascular endothelial cells express trypsinogen‐2 mRNA and its protein product in culture. The trypsinogen production was stimulated by a tumor promoter and associated with cell growth. In situ hybridization analysis showed that the trypsinogen gene was significantly expressed in vascular endothelial cells around gastric tumors and in patients with disseminated intravascular coagulation (DIC). These results suggest the possible roles of endothelial cell‐derived trypsin in tumor angiogenesis and abnormal blood coagulation.