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The complete inventory of the yeast Saccharomyces cerevisiae P‐type transport ATPases
Author(s) -
Catty Patrice,
de Kerchove d'Exaerde Alban,
Goffeau André
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)00446-8
Subject(s) - saccharomyces cerevisiae , genetics , biology , open reading frame , atpase , caenorhabditis elegans , yeast , phylogenetic tree , genome , tetrahymena , mutant , gene , computational biology , peptide sequence , biochemistry , enzyme
A total of sixteen open reading frames encoding for P‐type ATPases have been identified in the complete genome sequence of Saccharomyces cerevisiae . Phylogenetic analysis distinguishes 6 distinct families. Topology predictions, identification of aminoacid sequence motifs and phenotype analysis of the available mutants suggest that these families correspond to ATPases transporting either H + (2 members), Ca 2+ (2 members), Na + (3 members), heavy metals (2 members), possibly aminophospholipids (5 members including 4 new ones) or unknown substrates (2 new members). It is proposed that the latter family which has homologs in Tetrahymena thermophila , Plasmodium falciparum and Caenorhabditis elegans constitutes a new group called P4‐ATPases with characteristic topology and aminoacid signatures.