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Cyclic AMP signalling and cellular proliferation: regulation of CREB and CREM
Author(s) -
Della Fazia Maria Agnese,
Servillo Giuseppe,
Sassone-Corsi Paolo
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)00445-6
Subject(s) - creb , creb1 , repressor , leucine zipper , microbiology and biotechnology , adenylyl cyclase , biology , phosphorylation , regulation of gene expression , signal transduction , transcription factor , gene , genetics
In eukaryotes, transcriptional regulation upon stimulation of the adenylyl cyclase signalling pathway is mediated by a family of cAMP‐responsive nuclear factors. This family consists of a large number of members which may act as activators or repressors. These factors contain the basic domain/leucine zipper motifs and bind as dimers to cAMP‐response elements (CRE). The function of CRE‐binding proteins (CREB) is modulated by phosphorylation by the cAMP‐dependent protein kinase. The ICER (inducible cAMP early repressor) protein is the only inducible member of this family and is a product of the CREM gene. The induction of this powerful repressor is likely to be important for the transient nature of cAMP‐induced gene expression. CREB proteins have been found to play an important role in the physiology of neuroendocrine functions. In addition, recent results indicate that CREB and CREM could be involved in the proliferation of hepatocytes which follows partial hepatectomy.