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Rolling in the clover: trefoil factor family (TFF)‐domain peptides, cell migration and cancer
Author(s) -
Wright N.A,
Hoffmann W,
Otto W.R,
Rio M.-C,
Thim L
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)00424-9
Subject(s) - trefoil , mucin , peptide , cancer , transgene , knockout mouse , biology , microbiology and biotechnology , cancer research , chemistry , biochemistry , receptor , gene , genetics , agronomy
Trefoil factor family (TFF)‐domain peptides 1–3 are mucin‐associated molecules, largely found in epithelia of gastro‐intestinal tissues. Structurally similar, resistant to enzymatic degradation, they are up‐regulated around areas of epithelial damage such as ulcers. Transgenic expression or exogenous peptide ameliorates or prevents gastric mucosal damage due to indomethacin and some are rapidly up‐regulated after cryogenic burns. A role in promoting cell migration is strongly suggested. Knockout mice lacking TFF1 or TFF3 show significant pathology, with the former developing gastric tumours. A recent Conférence Philippe Laudat agreed upon a new nomenclature for these peptides.