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cGMP as second messenger during Dictyostelium chemotaxis
Author(s) -
van Haastert Peter J.M,
Kuwayama Hidekazu
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)00416-x
Subject(s) - second messenger system , adenylyl cyclase , dictyostelium , microbiology and biotechnology , chemotaxis , pde10a , protein kinase a , adcy10 , dictyostelium discoideum , myosin , chemistry , g protein , receptor , intracellular , signal transduction , biology , biochemistry , phosphorylation , gs alpha subunit , phosphodiesterase , enzyme , gene
The chemoattractant cAMP induces directed cell locomotion in Dictyostelium cells. Several second messenger pathways are activated upon binding of cAMP to G‐protein‐coupled receptors, including adenylyl cyclase, guanylyl cyclase, phospholipase C, and the opening of plasma membrane Ca 2+ channels. These second messenger responses are unaltered in many chemotactic mutants, except for the cGMP response. Activation of guanylyl cyclase depends on G‐proteins and is regulated by a cGMP‐binding protein in a complex manner. This cGMP‐binding protein also mediates intracellular functions of cGMP to activate a PKC‐related kinase that phosphorylates myosin II heavy chain, thereby allowing myosin filaments to rearrange during cell movement.