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Biochemistry and genetics of inositol phosphate metabolism in Dictyostelium
Author(s) -
van Haastert Peter J.M,
van Dijken Peter
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)00415-8
Subject(s) - inositol , dephosphorylation , inositol phosphate , phosphorylation , dictyostelium , biochemistry , metabolism , inositol trisphosphate receptor , biology , microbiology and biotechnology , chemistry , gene , receptor , phosphatase
Biochemical and genetic data on the metabolism of inositol phosphates in the microorganism Dictyostelium are combined in a scheme composed of in five subroutes. The first subroute is the inositol cycle as found in other organisms: inositol is incorporated into phospholipids that are hydrolysed by PLC producing Ins(1,4,5)P 3 which is dephosphorylated to inositol. The second subroute is the sequential phosphorylation of inositol to InsP 6 ; the Ins(3,4,6)P 3 intermediate does not release Ca 2+ . The third subroute is the sequential phosphorylation of Ins(1,4,5)P 3 to InsP 6 in a nucleus associated fraction, whereas the fourth subroute is the dephosphorylation of Ins(1,3,4,5,6)P 5 to Ins(1,4,5)P 3 at the plasma membrane. This last route mediates Ins(1,4,5)P 3 formation in cells with a disruption of the single PLC gene. Finally, we recognize the formation of InsP 7 and InsP 8 as the fifth subroute.