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Phosphatidylinositol transfer proteins: requirements in phospholipase C signaling and in regulated exocytosis
Author(s) -
Cockcroft Shamshad
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)00414-6
Subject(s) - phosphatidylinositol , phospholipase c , cytosol , exocytosis , microbiology and biotechnology , phospholipase d , phospholipase , phospholipid transfer protein , chemistry , phosphatidylcholine , pi , signal transduction , biochemistry , membrane , biology , enzyme , phospholipid
Phosphatidylinositol transfer proteins (PITP) are abundant cytosolic proteins originally identified because of their ability to act in vitro as specific transporters of phosphatidylinositol or phosphatidylcholine between membranes. However, the cellular function of mammalian PITP has remained enigmatic till recently. Due to the development of reconstitution assays in cytosol‐depleted cells, PITP was found to be an essential component for phospholipase C‐mediated hydrolysis of PIP 2 and for regulated exocytosis. The exact mechanism how PITP exerts its effects is not known but the PI binding/transfer activity of PITP can partly explain its cellular function. PITP would enable the local synthesis of PIP 2 by delivering PI to specialized signaling sites.