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Lysophosphatidic acid as a phospholipid mediator: pathways of synthesis
Author(s) -
Gaits Frédérique,
Fourcade Olivier,
Le Balle François,
Gueguen Geneviève,
Gaigé Bernadette,
Gassama-Diagne Ama,
Fauvel Josette,
Salles Jean-Pierre,
Mauco Gérard,
Simon Marie-Françoise,
Chap Hugues
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)00411-0
Subject(s) - lysophosphatidic acid , phosphatidic acid , lipid signaling , mediator , autotaxin , phospholipase d , phospholipid , biochemistry , receptor , chemistry , platelet activating factor , g protein coupled receptor , enzyme , phospholipase a2 , microbiology and biotechnology , biology , membrane , endocrinology
From very recent studies, including molecular cloning of cDNA coding for membrane receptors, lysophosphatidic acid (LPA) reached the status of a novel phospholipid mediator with various biological activities. Another strong argument supporting this view was the discovery that LPA is secreted from activated platelets, resulting in its appearance in serum upon blood coagulation. The metabolic pathways as well as the enzymes responsible for LPA production are poorly characterized. However, a survey of literature data indicates some interesting issues which might be used as the basis for further molecular characterization of phospholipases A able to degrade phosphatidic acid.