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The E. coli SRP: preferences of a targeting factor
Author(s) -
De Gier Jan-Willem L,
Valent Quido A,
Von Heijne Gunnar,
Luirink Joen
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)00402-x
Subject(s) - signal recognition particle , endoplasmic reticulum , protein targeting , cytoplasm , signal recognition particle receptor , microbiology and biotechnology , membrane protein , escherichia coli , inner membrane , function (biology) , secretory pathway , signal peptide , signal recognition particle rna , biology , chemistry , biochemistry , membrane , peptide sequence , gene , ribosome , rna , golgi apparatus
Research on the targeting of proteins to the cytoplasmic membrane of E. coli has mainly focused on the so‐called ‘general secretory pathway’ (GSP) which involves the Sec‐proteins. Recently, evidence has been obtained for an alternative targeting pathway in E. coli which involves the signal recognition particle (SRP). The constituents of this SRP pathway in E. coli are homologous to those of the well‐characterized eukaryotic SRP pathway, which is the main targeting pathway for both proteins translocated across and inserted into the endoplasmic reticulum membrane. However, until recently, no clear function could be assigned to the SRP in E. coli . New studies point to an important role of the E. coli SRP in the assembly of inner membrane proteins.