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Different utrophin and dystrophin properties related to their vascular smooth muscle distributions
Author(s) -
Rivier François,
Robert Agnès,
Hugon Gérald,
Mornet Dominique
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)00398-0
Subject(s) - utrophin , dystrophin , chemistry , microbiology and biotechnology , vascular smooth muscle , function (biology) , skeletal muscle , biology , biophysics , anatomy , endocrinology , smooth muscle
Monoclonal antibodies used to distinguish between dystrophin and utrophin were systematically applied to skeletal muscles containing arteries and veins. Small arteries were found to contain long forms of both utrophin and dystrophin, while small veins contained only long forms of utrophin. In addition, all sizes of vascular smooth muscles were demonstrated to contain another related M r 80 kDa protein (possibly a short utrophin transcript). Regardless of their tissue distributions, we assumed that each of these molecules had distinct properties, i.e. dystrophin with a mechanical function and utrophin with an architectural function. This difference in the roles of dystrophin and utrophin could reduce the efficiency of protection against muscle membrane degeneration when utrophin overexpression is programmed.