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Low‐conductance high selective inositol (1,4,5)‐trisphosphate activated Ca 2+ channels in plasma membrane of A431 carcinoma cells
Author(s) -
Kiselyov Kirill I.,
Mamin Anton G.,
Semyonova Svetlana B.,
Mozhayeva Gali.
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)00366-9
Subject(s) - inositol , conductance , chemistry , membrane , biophysics , biochemistry , biology , receptor , physics , condensed matter physics
In many cells, activation of receptors coupled to PIP 2 turnover results in Ca 2+ release from the intracellular stores accompanied by Ca 2+ influx across the PM. It is not well established yet whether Ca 2+ influx is activated by IP 3 or by an unknown signal generated upon Ca 2+ store depletion. We report here a single‐channel study of low‐conductance IP 3 ‐activated channels of very high selectivity for Ca 2+ in the PM of A431 carcinoma cells. The channels are strongly potential dependent and sensitive to [Ca 2+ ] i within the physiological range. The data obtained argues for IP 3 acting directly on plasma membrane Ca 2+ channels.