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Mitochondrial fatty acid synthesis: a relic of endosymbiontic origin and a specialized means for respiration
Author(s) -
Schneider Regina,
Brors Benedikt,
Massow Michael,
Weiss Hanns
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)00360-8
Subject(s) - biochemistry , mitochondrion , biology , fatty acid , phospholipid , oxidoreductase , enzyme , mitochondrial dna , mitochondrial carrier , gene , fatty acid synthesis , respiration , mitochondrial respiratory chain , chemistry , microbiology and biotechnology , bacterial outer membrane , botany , escherichia coli , membrane
Genes that encode mitochondrial homologues to the bacterial enzymes of fatty acid synthesis were found in various eukaryotic species. Inactivation of these genes leads to a disturbed mitochondrial respiration and an increase in mitochondrial lysophospholipids. We postulate that there is a mitochondrial biosynthetic system providing fatty acids for phospholipid repair. The mitochondrial acyl carrier protein may also play another role, supporting the formation of the respiratory NADH:ubiquinone oxidoreductase.