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The cytosolic aldehyde dehydrogenase gene ( Aldh1 ) is developmentally expressed in Leydig cells
Author(s) -
López-Fernández Luis A,
del Mazo Jesús
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)00352-9
Subject(s) - aldehyde dehydrogenase , retinoic acid , leydig cell , androgen receptor , biology , cytosol , endocrinology , medicine , androgen , gene , chemistry , microbiology and biotechnology , biochemistry , enzyme , genetics , hormone , luteinizing hormone , prostate cancer , cancer
Cytosolic aldehyde dehydrogenase, ALDH1, participates in the oxidation of different aldehydes including that of all‐ trans retinal to retinoic acid. The accumulation of mouse Aldh1 transcripts is characterized by having different patterns in different tissues. This paper reports the greatest expression of Aldh1 in testis and liver. It was demonstrated that in testis, Aldh1 is specifically expressed in Leydig cells and is under developmental regulation. In vitro studies of cultured Leydig TM3 cells confirmed these results though such gene expression was found not to be mediated by LH regulation. Previous investigations have associated androgen receptors, and hence the androgen insensitivity syndrome in man, with the presence of ALDH1 in genital skin fibroblasts. However, this relationship was not established in a functional cell type, as is reported here for Leydig cells. These results could suggest a model for a molecular pathway from androgen receptor to retinoic acid biogenesis in Leydig cells via the mediation of ALDH.