Premium
The protein encoded by the MFT1 gene is a targeting factor for mitochondrial precursor proteins, and not a core ribosomal protein
Author(s) -
Beilharz Traude,
Beddoe Travis,
Landl Karina,
Cartwright Peter,
Lithgow Trevor
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)00349-9
Subject(s) - ribosomal protein , hspa9 , gene , biology , snap23 , mitochondrion , ribosomal rna , mutant , microbiology and biotechnology , cytosol , locus (genetics) , genetics , ribosome , biochemistry , peptide sequence , rna , enzyme
Yeast cells harboring mft1 mutations are compromised in mitochondrial protein targeting, and Mft1p has previously been identified as a ribosomal protein. However, two genes, PLC2 and YML062C , are present in the MFT1 locus, and we show that mft1 mutant cells are compromised in the function of the cytosolic protein encoded by YML062C . The ribosomal protein (YS3a) is actually encoded by the tightly linked PLC2 gene, and does not play a role in targeting proteins to the mitochondria.