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Communication between the extracellular environment, cytoplasmic signalling cascades and the nuclear cell‐cycle machinery
Author(s) -
Peeper Daniel S,
Bernards René
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)00319-0
Subject(s) - microbiology and biotechnology , cell cycle , signal transduction , extracellular , cytoplasm , function (biology) , signalling , biology , cell cycle progression , cell division , cell , genetics
In the past decade, we have gained considerable insight into the identities of various cytoplasmic signal transduction cascades and the manner in which they operate in response to changes in the extracellular environment. Moreover, we have begun to understand what the key players are in cell‐cycle regulation and how they, in turn, function to promote cell division. A long‐standing question, however, has been how communication between signalling routes and the cell‐cycle machinery occurs. This review highlights some recent observations that provide possible links between signal transduction and the cell‐cycle machinery.