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Aberrant expression and function of p53 in T‐cells immortalized by HTLV‐I Tax1
Author(s) -
Akagi Tsuyoshi,
Ono Hiroaki,
Tsuchida Nobuo,
Shimotohno Kunitada
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)00280-9
Subject(s) - immortalised cell line , suppressor , function (biology) , cell culture , microbiology and biotechnology , biology , in vitro , chemistry , gene , genetics
The expression and function of p53 tumor suppressor protein was investigated in T‐cells immortalized by the Tax1 protein of HTLV‐I. Conformationally wild‐type p53 was expressed at elevated levels in Tax1‐immortalized T‐cells by post‐transcriptional mechanisms when compared with normal T‐cells. Luciferase assays with a reporter plasmid containing p53‐binding sites revealed an impairment in the transactivating function of p53 in Tax1‐immortalized T‐cells. Our results suggest an important role for Tax1 in the aberrant expression and function of p53 observed in many HTLV‐I transformed cells.