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Human osteosarcoma cell susceptibility to natural killer cell lysis depends on CD54 and increases after TNFα incubation
Author(s) -
Mariani Erminia,
Tarozzi Andrea,
Meneghetti Alessandra,
Cattini Luca,
Facchini Andrea
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)00247-0
Subject(s) - cytolysis , lysis , tumor necrosis factor alpha , cell , cell adhesion molecule , osteosarcoma , natural killer cell , in vitro , biology , cytotoxicity , cell adhesion , lymphokine activated killer cell , cancer research , immunology , chemistry , microbiology and biotechnology , interleukin 12 , cytotoxic t cell , biochemistry
Osteosarcoma cell lines vary widely in their susceptibility to natural killer (NK) cell lysis in vitro although it is still unclear why this occurs. In this study we investigated the expression of some cell adhesion molecules on osteosarcomas to determine which of these can modify the susceptibility to NK lysis and we also attempted to modulate the cytolytic susceptibility of these targets with TNFα. We found that osteosarcoma lysis induced by NK cells correlates with different expression of the CD54 adhesion molecule on osteosarcomas and the increased susceptibility after TNFα treatment mostly depends on the expression of CD54 molecules on target cells.