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Photoactivation of the nitric oxide donor SIN‐1
Author(s) -
Ullrich Thomas,
Oberle Stefanie,
Abate Aida,
Schröder Henning
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)00239-1
Subject(s) - molsidomine , nitric oxide , oxygen , chemistry , metabolite , irradiation , nitrite , photochemistry , biophysics , visible spectrum , nuclear chemistry , biochemistry , nitrate , materials science , organic chemistry , biology , physics , optoelectronics , nuclear physics
This study investigates whether nitric oxide (NO) release from linsidomine (SIN‐1), the active metabolite of the antianginal drug molsidomine, is light sensitive. A 9‐h irradiation with polychromatic visible light increased the formation of nitrite (NO index metabolite) from SIN‐1 (1 mM) by 61% as compared to control samples incubated in the dark. Under the same conditions (9‐h irradiation) the concentration of oxygen decreased to 2% of control. However, oxygen consumption was substantially reduced when light was excluded (35% recovery after 9 h). These results show that irradiation with visible light markedly enhances the oxygen‐dependent NO release from SIN‐1. Thus, sydnonimines appear to be suitable model compounds for the development of photoactivatable NO donors.