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Cytotoxic protein from human platelets
Author(s) -
Golubeva T.S.,
Paromov V.M.,
Tuguz A.R.,
Chertov O.Yu.,
Kiselevsky M.V.
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)00205-6
Subject(s) - cytotoxic t cell , cls upper limits , platelet , chemistry , biochemistry , peptide sequence , microbiology and biotechnology , biology , immunology , gene , medicine , in vitro , optometry
The 14 kDa protein was purified from human platelets. It displays high cytotoxic activity to the human ACL cells at 10 M concentration (21.8±7.1%). Its N‐terminal sequence is YAPQXQFGP–, being highly homologous to region 241–249 residues of the human Cls complement component.